Motor Pathway Injury with Periventricular Leukomalacia and Spastic Diplegia

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Motor pathway injury in patients with periventricular leucomalacia and spastic diplegia.

Periventricular leucomalacia has long been investigated as a leading cause of motor and cognitive dysfunction in patients with spastic diplegic cerebral palsy. However, patients with periventricular leucomalacia on conventional magnetic resonance imaging do not always have motor dysfunction and preterm children without neurological abnormalities may have periventricular leucomalacia. In additio...

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Leucomalácia periventricular e diplegia espástica: implicações nas habilidades psicolingüísticas*** Periventricular leukomalacia and spastic diplegia: implications in the psycholinguistic abilities

Background: spastic diplegic cerebral palsy (D-CP) is frequently related to periventricular leukomalacia (PVL), which usually affects the descending motor fibers of the association cortex and association fibers of the visual, auditory and somesthesic functions. Aim: to verify the performance of children with D-CP regarding their psycholinguistic skills. Method: participants were eight individua...

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Nitrosative and oxidative injury to premyelinating oligodendrocytes in periventricular leukomalacia.

Periventricular leukomalacia (PVL), the major substrate of cerebral palsy in survivors of prematurity, is defined as focal periventricular necrosis and diffuse gliosis in immature cerebral white matter. We propose that nitrosative and/or oxidative stress to premyelinating oligodendrocytes complicating cerebral ischemia in the sick premature infant is a key mechanism of injury interfering with m...

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Pontine hypoplasia in children with periventricular leukomalacia.

BACKGROUND AND PURPOSE The brain stem in patients with periventricular leukomalacia (PVL) appears smaller than normal on MR imaging, but few reports have described this feature, and the number of patients has been relatively small. The present study was conducted to examine the hypothesis that the pons in patients with PVL is smaller than normal. MATERIALS AND METHODS Using MR imaging, we exa...

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Neurodevelopmental outcome in children with periventricular leukomalacia.

The purpose of this study was to question the correlation of different grades of periventricular leukomalacia (PVL) and subsequent neurodevelopmental outcome. In a prospective study we followed 52 preterm infants. Infants were divided into three groups according to their cranial ultrasound findings of PVL (De Vries classification). Seventeen children had PVL 1, 20 children had PVL 2, and 15 chi...

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ژورنال

عنوان ژورنال: Pediatric Neurology Briefs

سال: 2011

ISSN: 2166-6482,1043-3155

DOI: 10.15844/pedneurbriefs-25-6-1