Motions of Tropomyosin

Tropomyosin antibody: the specific localization of tropomyosin in nonmuscle cells

An antibody against purified chicken skeletal muscle tropomyosin is used in indirect immunofluorescence to visualize the localization of tropomyosin in a variety of nonmuscle cells. The antibody produces a fluorescent pattern which is very similar to that obtained with an actin-specific antibody. This pattern is composed of fluorescent fibers which are shown to be coincident with the fibers see...

Tropomyosin keeps actin tough

Actin (green) and ADF/cofilin (red) are disorganized in the absence of tropomyosin (bottom). ntracellular parasites must walk a fine line, invading and exploiting a host cell without killing it too quickly. On page 1029, Glomski et al. show how a single amino acid determines not only the pH I optimum of a bacterial hemolysin, but also the virulence of an important pathogen. The data help explai...

[Motions].

A small molecule inhibitor of tropomyosin dissociates actin binding from tropomyosin-directed regulation of actin dynamics

The tropomyosin family of proteins form end-to-end polymers along the actin filament. Tumour cells rely on specific tropomyosin-containing actin filament populations for growth and survival. To dissect out the role of tropomyosin in actin filament regulation we use the small molecule TR100 directed against the C terminus of the tropomyosin isoform Tpm3.1. TR100 nullifies the effect of Tpm3.1 on...

Wavelet-based Analysis for Pulse Period of Earthquake Ground-motions

Pulse period of earthquake records has been known as a key parameter in seismology and earthquake engineering. This paper presents a detailed characterization of this parameter for a special class of earthquake records called pulse-like ground motions. This type of motions often resulting from directivity effects is characterized by a strong pulse in the velocity time history of motion, in norm...