منابع مشابه
Mossy fiber sprouting interacts with sodium channel mutations to increase dentate gyrus excitability.
PURPOSE Idiopathic epilepsy is caused by the complex interaction of genetic and environmental factors. The purpose of this study was to use computational approaches to explore the interaction between changes in sodium channel availability caused by mutations and mossy fiber sprouting. METHODS We used a previously published biophysically realistic computer model of dentate gyrus neurons and ne...
متن کاملRole of mossy fiber sprouting and mossy cell loss in hyperexcitability: a network model of the dentate gyrus incorporating cell types and axonal topography.
Mossy cell loss and mossy fiber sprouting are two characteristic consequences of repeated seizures and head trauma. However, their precise contributions to the hyperexcitable state are not well understood. Because it is difficult, and frequently impossible, to independently examine using experimental techniques whether it is the loss of mossy cells or the sprouting of mossy fibers that leads to...
متن کاملCharacterization of target cells for aberrant mossy fiber collaterals in the dentate gyrus of epileptic rat.
Previous studies have demonstrated formation of recurrent excitatory circuits between sprouted mossy fibers and granule cell dendrites in the inner molecular layer of the dentate gyrus (9, 28, 30). In addition, there is evidence that inhibitory nonprincipal cells also receive an input from sprouted mossy fibers (39). This study was undertaken to further characterize possible target cells for sp...
متن کاملHilar mossy cells of the dentate gyrus: a historical perspective
THE CIRCUITRY OF THE DENTATE GYRUS (DG) OF THE HIPPOCAMPUS IS UNIQUE COMPARED TO OTHER HIPPOCAMPAL SUBFIELDS BECAUSE THERE ARE TWO GLUTAMATERGIC PRINCIPAL CELLS INSTEAD OF ONE: granule cells, which are the vast majority of the cells in the DG, and the so-called "mossy cells." The distinctive appearance of mossy cells, the extensive divergence of their axons, and their vulnerability to excitotox...
متن کاملActions of brain-derived neurotrophic factor in slices from rats with spontaneous seizures and mossy fiber sprouting in the dentate gyrus.
This study examined the acute actions of brain-derived neurotrophic factor (BDNF) in the rat dentate gyrus after seizures, because previous studies have shown that BDNF has acute effects on dentate granule cell synaptic transmission, and other studies have demonstrated that BDNF expression increases in granule cells after seizures. Pilocarpine-treated rats were studied because they not only hav...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2010
ISSN: 0013-9580
DOI: 10.1111/j.1528-1167.2010.02825.x