Morphometric scores for kidney tumours: Use in current practice

Cardiovascular disease risk scores in the current practice: which to use in rheumatoid arthritis?

Cardiovascular disease (CVD) is the highest prevalence disease in the general population (GP) and it accounts for 20 million deaths worldwide each year. Its prevalence is even higher in rheumatoid arthritis. Early detection of subclinical disease is critical and the use of cardiovascular risk prediction models and calculators is widely spread. The impact of such techniques in the GP was previou...

Kidney Tumours

Introduction A variety of benign and malignant tumours can arise in the kidney in children. With minor variations, the spectrum of tumours has worldwide distribution. Wilms’ tumour (WT; also known as nephroblastoma) is the most common kidney tumour in childhood, and may represent the most common abdominal tumour presenting in infants and children in sub-Saharan Africa. In the past decade, consi...

Current practice Antiplatelet use in interventional cardiology

Thrombosis within the target vessel is one of the most feared complications associated with coronary intervention, as it is often associated with severe adverse clinical sequelae. This thrombosis is mediated via the activation and aggregation of platelets and therefore considerable eVort has been directed at ways of inhibiting platelet function. It is now mandatory to consider the use of two an...

Ketamine use in current clinical practice

Current and future developments in the use of temozolomide for the treatment of brain tumours.

Brain tumours comprise only 2% of all adult cancers, but they are among the most debilitating malignant diseases. Temozolomide, an alkylating agent that can be administered orally, has been approved for the treatment of recurrent malignant glioma on a daily schedule for 5-day cycles. Continuous administration schedules with a higher dose intensity are being explored, but an improvement in effic...