Morphological changes associated with reoxygenation in adult cardiac myocytes
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چکیده
منابع مشابه
Cardiac myocytes exposed to anoxia-reoxygenation promote neutrophil transendothelial migration.
The goal of the present study was to assess whether cardiac myocytes exposed to anoxia-reoxygenation (A/R) could generate a chemotactic gradient for polymorphonuclear neutrophil (PMN) transendothelial migration. Exposure of neonatal mouse cardiac myocytes to A/R induced an oxidant stress in the myocytes. Supernatants obtained from A/R-conditioned myocytes promoted mouse PMN migration across mou...
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Confocal microscopy was used to study the properties of nuclear Ca2+ regulation in adult ventricular myocytes. Prolonged nuclear Ca2+ release (PNCR) events were identified in both intact and permeabilized rat myocytes. PNCR occurred spontaneously and was restricted to localized regions at the ends of the elongated nuclei. Typically, PNCR took the form of a rapid rise in [Ca2+] followed by a mai...
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Confocal microscopy was used to study the properties of nuclear Ca regulation in adult ventricular myocytes. Prolonged nuclear Ca release (PNCR) events were identified in both intact and permeabilized rat myocytes. PNCR occurred spontaneously and was restricted to localized regions at the ends of the elongated nuclei. Typically, PNCR took the form of a rapid rise in [Ca ] followed by a maintain...
متن کاملMorphological and functional changes in cardiac myocytes isolated from mice overexpressing TNF-alpha.
Transgenic (TG) TNF1.6 mice, which cardiac specifically overexpress tumor necrosis factor-alpha (TNF-alpha), exhibit heart failure (HF) and increased mortality, which is markedly higher in young (<20 wk) males (TG-M) than females (TG-F). HF in this model may be partly caused by remodeling of the extracellular matrix and/or structure/function alterations at the single myocyte level. We studied l...
متن کاملHypoxia/Reoxygenation Cardiac Injury and Regeneration in Zebrafish Adult Heart
AIMS the adult zebrafish heart regenerates spontaneously after injury and has been used to study the mechanisms of cardiac repair. However, no zebrafish model is available that mimics ischemic injury in mammalian heart. We developed and characterized zebrafish cardiac injury induced by hypoxia/reoxygenation (H/R) and the regeneration that followed it. METHODS AND RESULTS adult zebrafish were ...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2001
ISSN: 1582-1838,1582-4934
DOI: 10.1111/j.1582-4934.2001.tb00154.x