Morphine at inflammatory experimental pain: A review

Pain is a complex entity that can be described in several dimensions, such as, acute pain and chronic pain, characterized by its duration. After the tissue injury, activation of sensory nervous occurs from where different pro-inflammatory mediators are released with consequent nociceptive transmission characterizes genesis inflammatory pain. The main objective this study was to review role opioid system, using morphine MOR receptors as paradigm, antinociceptive modulation means formalin test model. Various pieces evidence compiled establish fundamental Morphine has noticeable efficacy decrease This demonstrates plays states it could serve basis for new pharmacotherapy