Montelukast exerts no acute direct effect on NO synthases
نویسندگان
چکیده
منابع مشابه
Hydrochlorothiazide exerts no direct vasoactivity in the human forearm.
BACKGROUND Recently, hydrochlorothiazide has been shown to relax vascular smooth muscle in vitro in clinically relevant concentrations by the opening of calcium-activated potassium channels, leading to hyperpolarization and consequent closing of voltage-operated calcium channels. Long-term administration of hydrochlorothiazide reduces peripheral vascular resistance in vivo in man. These results...
متن کاملDiverse Functions of Endothelial NO Synthases System: NO and EDH
Endothelium-dependent relaxations are predominantly regulated by nitric oxide (NO) in large conduit arteries and by endothelium-dependent hyperpolarization (EDH) in small resistance vessels. Although the nature of EDH factors varies depending on species and vascular beds, we have previously demonstrated that endothelial NO synthases (eNOS)-derived hydrogen peroxide (H2O2) is an EDH factor in an...
متن کاملRole of NO in cyclosporin nephrotoxicity: effects of chronic NO inhibition and NO synthases gene expression.
The role of nitric oxide (NO) during cyclosporin renal vasoconstriction was evaluated by glomerular hemodynamic and histological changes produced by chronic NO synthesis inhibition and neuronal (nNOS), inducible (iNOS), and endothelial (eNOS) NO synthases mRNA expression in renal cortex and medulla. Uninephrectomized rats treated during 7 days with vehicle (Veh), cyclosporin A (CsA) 30 mg/kg, C...
متن کاملHappiness and unhappiness have no direct effect on mortality
822 www.thelancet.com Vol 387 February 27, 2016 What defi nes a good life? If in answering this question you included happiness in your list, you are not alone. Indeed, the pursuit and enjoyment of happiness is a common goal and desire in life for most people. Adults of all ages, including those in old age, frequently report the experience of happiness as a determinant of a good life. Since bot...
متن کاملOxygen activation in NO synthases: evidence for a direct role of the substrate
Nitric oxide (NO) and the other reactive nitrogen species (RNOS) play crucial patho-physiological roles at the interface of oxidative stress and signalling processes. In mammals, the NO synthases (NOSs) are the source of these reactive nitrogen species, and so to understand the precise biological role of RNOS and NO requires elucidation of the molecular functioning of NOS. Oxygen activation, wh...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pulmonary Pharmacology & Therapeutics
سال: 2007
ISSN: 1094-5539
DOI: 10.1016/j.pupt.2006.05.001