Monotherapy or Polytherapy for First-Line Treatment of SE?
نویسندگان
چکیده
منابع مشابه
Monotherapy or polytherapy for epilepsy?
Monotherapy has been promoted as the ideal in epilepsy treatment because of reduced side effects, absence of drug interactions, better compliance, lower cost and, in many cases, improved seizure control compared to polytherapy. The question of monotherapy vs. polytherapy has assumed increasing importance with the availability of multiple new antiepileptic drugs (AEDs), initially tested as add-o...
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The Nottingham ePrints service makes this work by researchers of the University of Nottingham available open access under the following conditions. This article is made available under the Creative Commons Attribution licence and may be reused according to the conditions of the licence. For more details see: A note on versions: The version presented here may differ from the published version or...
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Some investigators argue that treating epilepsy with several antiepileptic drugs (AEDs) simultaneously (polytherapy) may give rise to more adverse effects than monotherapy, but this argument lacks supporting quantitative data. To reexamine this issue, we recruited a cohort of patients from the outpatients of the Special Centres for Epilepsy in The Netherlands and from the outpatients of the Dep...
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For patients with epilepsy, the goal of treatment is to achieve seizure freedom with minimal or no adverse events. Around 60%-70% of newly diagnosed patients will achieve this goal with single antiepileptic drug (AED) therapy, and there is universal agreement that prescription of a single agent constitutes best practice for such patients. For the 30%-40% of patients with poorly controlled epile...
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The goal of epilepsy therapy is to help patients achieve seizure freedom without adverse effects. While monotherapy is preferable in epilepsy treatment, many patients fail a first drug due to lack of efficacy or failure to tolerate an initial medication, necessitating an alteration in therapy. Sudden changes between monotherapies are rarely feasible and sometimes deleterious given potential haz...
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ژورنال
عنوان ژورنال: Journal of Clinical Neurophysiology
سال: 2016
ISSN: 0736-0258
DOI: 10.1097/wnp.0000000000000217