Monosomal karyotype in MDS: explaining the poor prognosis?
نویسندگان
چکیده
منابع مشابه
Poor Prognosis in Acute Myeloid Leukemia Patients with Monosomal Karyotypes
OBJECTIVE This study aimed to investigate the clinical characteristics and prognostic significance of monosomal karyotypes (MKs) in patients with acute myeloid leukemia (AML). MATERIALS AND METHODS We retrospectively analyzed the clinical data for 498 patients with AML, of whom 233 (46.8%) had an abnormal karyotype, including 42 with MKs (8.4%) and 70 with a complex karyotype (CK) (14.1%). ...
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A 24-year-old woman presented to her primary care physician for persistent bilateral otitis media and frequent night sweats. Laboratory evaluation revealed a white blood cell count of 26 000/mL with 84% blasts on differential, hemoglobin 6.8 g/dL, and platelet 90 000/mL. Her total serum lactate dehydrogenase level was 888 U/L. She underwent a diagnostic bone marrow aspirate and biopsy, which de...
متن کاملTherapeutic implications of monosomal karyotype AML?
Therapeutic implications of monosomal karyotype AML? The excessively poor prognostic subgroup of AML with MK is explained by resistance against current treatment modalities resulting in a low CR percentage. CRs achieved following 3+7 anthracyclin-cytarabine induction chemotherapy in MK-AML are of poor quality which is evident from the high and early relapse rate after CR. This high relapse rate...
متن کاملMonosomal karyotype in myeloid neoplasias: a literature review
In 2008, the concept of the monosomal karyotype (MK) in adult acute myeloid leukemia (AML) patients was introduced, defined by the presence of a chromosomal aberration pattern characterized by the presence of at least two autosomal monosomies or of one monosomy plus one or more structural aberrations (not including loss of a chromosome). We present a systematic review of the literature about th...
متن کاملCytogenetic Profile of Monosomal Karyotype in Adult Acute Myeloid Leukemia
Cytogenetic abnormalities at diagnosis are important prognostic indicators in acute myeloid leukemia (AML). AML is categorized into 3 risk groups according to cytogenetic abnormalities; favorable, intermediate, and unfavorable. A new cytogenetic risk group called the monosomal karyotype (MK) had been identified in AML in the unfavorable cytogenetic risk group. The MK was reported to be associat...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2013
ISSN: 0887-6924,1476-5551
DOI: 10.1038/leu.2013.187