Monocytosis, Hypercholesterolemia, and the Kinase That Binds Them
نویسندگان
چکیده
منابع مشابه
Monocytosis, Hypercholesterolemia, and the Kinase That Binds Them.
Atherosclerosis is a chronic lipid-driven inflammatory disease that involves the recruitment, infiltration, differentiation, and proliferation of monocytes and monocyte-derived macrophages. In the absence of these cells, disease neither initiates nor progresses. Indeed, leukocytosis is a defining risk factor for increased cardiovascular disease in humans. Because monocytes are involved in every...
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Macrophage accumulation participates decisively in the development and exacerbation of atherosclerosis. Circulating monocytes, the precursors of macrophages, display heterogeneity in mice and humans, but their relative contribution to atherogenesis remains unknown. We report here that the Ly-6C(hi) monocyte subset increased dramatically in hypercholesterolemic apoE-deficient mice consuming a hi...
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BACKGROUND The target of rapamycin (TOR), in complex with the proteins raptor and LST8 (TOR complex 1), phosphorylates the p70S6K and 4E-BP1 to promote mRNA translation. Genetic evidence establishes that TOR complex activity in vivo requires the small GTPase Rheb, and overexpression of Rheb can rescue TOR from inactivation in vivo by amino-acid withdrawal. The Tuberous Sclerosis heterodimer (TS...
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Background: The prevalence of hypercholesterolemia is increasing globally. It is associated with a significant risk of developing type 2 diabetes mellitus and cardiovascular diseases. The aim of the current study was to explore the relationship of nutrients patterns and other lifestyle-related factors with the presence of hypercholesterolemia in a representative population of Iran. Methods: Die...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2017
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.116.308768