Monocyte Telomere Shortening and Oxidative DNA Damage in Type 2 Diabetes
نویسندگان
چکیده
منابع مشابه
Monocyte telomere shortening and oxidative DNA damage in type 2 diabetes.
OBJECTIVE Telomeres are DNA sequences necessary for DNA replication, which shorten at cell division at a rate related to levels of oxidative stress. Once shortened to a critical length, cells are triggered into replicative senescence. Type 2 diabetes is associated with oxidative DNA damage, and we hypothesized that telomere shortening would characterize type 2 diabetes. RESEARCH DESIGN AND ME...
متن کاملOxidative DNA damage and obesity in type 2 diabetes mellitus.
OBJECTIVE This study illustrates the relationship between oxidative DNA damage and obesity in patients with prediabetes and type 2 diabetes compared with controls. DESIGN AND METHODS Participants attended the School of Community Health, Diabetes Screening Clinic, Charles Sturt University, Australia, between February 2006 and June 2008. A total of 162 participants (35 type 2 diabetic patients;...
متن کاملLack of association of colonic epithelium telomere length and oxidative DNA damage in Type 2 diabetes under good metabolic control
BACKGROUND Telomeres are DNA repeat sequences necessary for DNA replication which shorten at cell division at a rate directly related to levels of oxidative stress. Critical telomere shortening predisposes to cell senescence and to epithelial malignancies. Type 2 diabetes is characterised by increased oxidative DNA damage, telomere attrition, and an increased risk of colonic malignancy. We hypo...
متن کاملOxidative Stress, DNA Damage and DNA Repair in Female Patients with Diabetes Mellitus Type 2
BACKGROUND Diabetes mellitus type 2 (T2DM) is associated with oxidative stress which in turn can lead to DNA damage. The aim of the present study was to analyze oxidative stress, DNA damage and DNA repair in regard to hyperglycemic state and diabetes duration. METHODS Female T2DM patients (n = 146) were enrolled in the MIKRODIAB study and allocated in two groups regarding their glycated hemog...
متن کاملDifferential Telomere Shortening in Blood versus Arteries in an Animal Model of Type 2 Diabetes
Vascular dysfunction is an early feature of diabetic vascular disease, due to increased oxidative stress and reduced nitric oxide (NO) bioavailability. This can lead to endothelial cell senescence and clinical complications such as stroke. Cells can become senescent by shortened telomeres and oxidative stress is known to accelerate telomere attrition. Sirtuin 1 (SIRT1) has been linked to vascul...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Diabetes Care
سال: 2006
ISSN: 0149-5992,1935-5548
DOI: 10.2337/diacare.29.02.06.dc05-1715