Monoclonal Antibody Clearance

Ofatumumab Monoclonal Antibody Affinity Maturation Through in silico Modeling

Background: Ofatumumab, an anti-CD20 mAb, was approved in 2009 for the treatment of chronic lymphocytic leukemia. This mAb acts through immune-mediated mechanisms, in particular complement-dependent cytotoxicity and antibody-dependent cellular cytotoxicity by natural killer cells as well as antibody-dependent phagocytosis by macrophages. Apoptosis induction is another mechanism of this antibody...

Development of a Novel Inhibitory Chimeric Anti-HER2 Monoclonal Antibody

Immunospecific saturable clearance mechanisms for indium-111-labeled anti-melanoma monoclonal antibody 96.5 in humans.

Liver uptake of 111In-labeled monoclonal antibodies (MoAb) remains a significant problem in radioimaging studies to date. To determine if the observed liver uptake of an 111In-labeled anti-melanoma antibody 96.5 (111In-96.5) was dependent on the presence of hepatic antigen or on recognition of circulating murine antibody, escalating doses of an unlabeled nonimmunoreactive MoAb (NIR-MoAb) were a...

ImmunospecifÃ-cSaturable Clearance Mechanisms for Indium-Ill-labeled Anti-Melanoma Monoclonal Antibody 96.5 in Humans'

Liver uptake of '"In-labeled monoclonal antibodies (MoAb) remains a significant problem in radioimaging studies to date. To determine if the observed liver uptake of an '"In-labeled anti-melanoma antibody 96.5 ('"In-96.5) was dependent on the presence of hepatic antigen or on recognition of circulating murine antibody, escalating doses of an unlabeled nonimmunoreactive MoAb (NIR-MoAb) were admi...

Clearance of persistent hepatitis C virus infection using a claudin-1-targeting monoclonal antibody

Laurent Mailly, Fei Xiao*, Joachim Lupberger*, Garrick K. Wilson, Philippe Aubert, François H. T. Duong, Diego Calabrese, Céline Leboeuf, Isabel Fofana, Christine Thumann, Simonetta Bandiera, Marc Lütgehetmann, Tassilo Volz, Christopher Davis, Helen J. Harris, Christopher J. Mee, Erika Girardi, Béatrice Chane-Woon-Ming, Maria Ericsson, Nicola Fletcher, Ralf Bartenschlager, Patrick Pessaux, Koen...