Monitoring the bisphosphonate treatment holiday
نویسندگان
چکیده
منابع مشابه
Increase in the Serum Parathyroid Hormone Level During a Bisphosphonate Drug Holiday
After discontinuation of bisphosphonate therapy, an antiresorptive effect and antifracture protection persist for an undefined period. Patients are encouraged to continue calcium and vitamin D supplementation, during a bisphosphonate drug holiday. However, assessment of adequate calcium intake during the bisphosphonate drug holiday is difficult. Therefore, we measured the serum intact parathyro...
متن کاملEffects of a 'Drug Holiday' on Bone Mineral Density and Bone Turnover Marker During Bisphosphonate Therapy
BACKGROUND Recently long-term safety of bisphosphonate raises issues about the duration of therapy. We examined the effects of a drug holiday (DH) on bone mineral density (BMD) and bone turnover markers. METHODS In Korean, 125 women of 50 years of age or older with T-score≤-3.0 of their lumbar or left femoral BMD initiated bisphosphonate from 1999 based on retrospective chart review. 125 pati...
متن کاملRenal complications from bisphosphonate treatment.
PURPOSE OF REVIEW More than 10 years ago evidence emerged that bisphosphonate therapy especially in malignant bone diseases is associated with renal complications. The nature of renal injury from bisphosphonates has become clearer in recent years. RECENT FINDINGS Pamidronate can rarely cause (collapsing) focal segmental glomerular sclerosis with the nephrotic syndrome and renal insufficiency....
متن کاملBisphosphonate treatment recommendations for oncologists.
Renal safety is an important consideration for oncologists who are treating patients with bisphosphonates. In recent years, there has been increasing awareness about the development of bisphosphonate-induced nephrotoxicity. This has emerged mainly from increased clinical experience with zoledronic acid (Zometa); Novartis Pharmaceuticals Corporation, East Hanover, NJ, http://www.pharma.us.novart...
متن کاملRECENT ADVANCES Bisphosphonate treatment of bone disease
MECHANISM OF ACTION AND RELATIVE POTENCY Bisphosphonates are chemical analogues of pyrophosphate. The presence of a carbon rather than oxygen atom at the centre of the molecule prevents its breakdown. The two phosphonate groups are attached directly to the carbon atom from which also extend the R1 and R2 side chains (fig 1). The R1 side chain is usually a hydroxyl group and is often referred to...
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ژورنال
عنوان ژورنال: Endocrine Abstracts
سال: 2014
ISSN: 1479-6848
DOI: 10.1530/endoabs.34.p7