MON-025 Activin a Increases Human Trophoblast Invasion by Up-Regulating Integrinb1 Through ALK4
نویسندگان
چکیده
منابع مشابه
Activin-A up-regulates type I activin receptor mRNA levels in human immortalized extravillous trophoblast cells.
Activin is known to play an important regulatory role in reproduction, including pregnancy. To further examine the role and signaling mechanism of activin in regulating placental function, the steady-state level of activin type I receptor (ActRI) mRNA in immortalized extravillous trophoblasts (IEVT) cells was measured using competitive PCR (cPCR). An internal standard of ActRI cDNA for cPCR was...
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The ligand-dependent nuclear receptors PPAR and RXR / were recently determined to be essential for murine placental development and trophoblast differentiation. In the current study we examined the expression and role of the PPAR / RXR heterodimers in human invasive trophoblasts. We first report that in human first trimester placenta, PPAR and RXR are highly expressed in cytotrophoblasts at the...
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ژورنال
عنوان ژورنال: Journal of the Endocrine Society
سال: 2020
ISSN: 2472-1972
DOI: 10.1210/jendso/bvaa046.398