Molecules in metastasis

Metastasis movies, macrophages, molecules and more

Introduction This timely and illuminating conference revealed that the study of metastatic disease is advancing at a rapid pace. No longer simply descriptive or phenomenological, the investigation of malignancy is now a modern, molecular endeavour that takes advantage of complex genetic manipulations, sophisticated mouse models and real-time in vivo imaging techniques, as well as global analyse...

Invasion and Metastasis in the Viewpoint of Cell Adhesive Molecules

cell signaling pathways of transmembrane protein kinases such as receptor tyrosine kinase. However, they are also known to be involved in a wide range of other biological activities, including immune patrolling, cell migration, and binding of certain viruses to cells [3]. Invasion and metastasis are two distinguishing characteristics of cancer. These distort or disjoint the stable cell-cell and...

Spermatozoa Molecules in Relation to Bulls Fertility

Bull fertility may be defined as the process by which spermatozoa fertilize and activate the ovum and then support embryonic development. Bull fertility is a complex trait having relatively low heritability and plays a vital role for efficient production and reproduction of bovine. Various mechanisms involved in regulating bull fertility associated phenotype and reliable biomarkers are poorly d...

Ovarian Metastasis in Endometriod Type Endometrial Cancer

Palmitoylated claudin7 captured in glycolipid-enriched membrane microdomains promotes metastasis via associated transmembrane and cytosolic molecules

In epithelial cells claudin7 (cld7) is a major component of tight junctions, but is also recovered from glycolipid-enriched membrane microdomains (GEM). In tumor cells, too, cld7 exists in two stages. Only GEM-located cld7, which is palmitoylated, promotes metastasis. Searching for the underlying mechanism(s) revealed the following.The metastatic capacity of the rat pancreatic adenocarcinoma ce...