منابع مشابه
Chemical characteristics of a high molecular weight renin from the renal cortex of the dog.
We found an acid extract of normal dog kidneys to contain two distinct molecular weight forms of renin-like activity. Gel filtration chromatography showed peaks of activity as estimated molecular weights of 65,000 and 41,000. The high molecular weight fraction (HMW) comprised only 1% of the total activity of the extract. Both HMW and low molecular weight (LMW) fractions were inhibited by anti-h...
متن کاملInactive Renin of High Molecular Weight (Big Renin) in Normal Human Plasma
Normal plasma contains inactive renin, which becomes active when plasma is dialyzed to pH 3.3 and to pH 7.5, or treated with pepsin or trypsin. Under optimal conditions, each of these procedures activated the same quantity of renin, which was not further increased by repeating or combining two procedures, thus suggesting that the same pool of inactive renin was activated by each procedure. When...
متن کاملStudies on high molecular weight renin from hog kidney.
blood pressure in hypertensive rau. Clin Exp Pharmacol Physiol Suppl 2: 201-205, 1975 15. Furchgott RF, Bhadrakom S: Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs. J Pharmacol Exp Ther 108: 129-143, 1953 16. Rondell P, Gross F: Method for isometric recording from isolated vessels under various conditions. Helv Physiol Acta 18: 366-375, 19...
متن کاملSpecific renal delivery of sugar-modified low-molecular-weight peptides.
To develop a novel delivery system for peptides involving sugar modification, Arg-vasopressin (AVP) was modified by linking it to a variety of sugars via an octamethylene group and the subsequent tissue uptake by rats was then monitored after administration by i.v. injection. The glucosyl, mannosyl, and 2-deoxyglucosyl derivatives of AVP exhibited selective renal uptake. These derivatives were ...
متن کاملMonoclonal antibodies binding renal renin.
Somatic-cell fusion of normal antibody-producing spleen cells with cells from a plasmacytoma culture results in a culture of hybrid cells from which a monoclonal line may be selected. These lines are immortal and may be amplified as tumors in syngeneic animals to produce large quantities of antibodies characterized by molecular homogeneity. We report the application of this technique to the pro...
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ژورنال
عنوان ژورنال: Japanese Heart Journal
سال: 1980
ISSN: 0021-4868,1348-673X
DOI: 10.1536/ihj.21.205