Molecular therapies delaying cardiovascular aging: disease- or health-oriented approaches

Proponent or collaborative: Physician perspectives and approaches to disease modifying therapies in sickle cell disease

Sickle cell disease (SCD) is an inherited blood disorder that primarily affects African-American and other ethnic minority populations. There are three available disease-modifying therapies for sickle cell disease: hydroxyurea (HU), bone marrow transplantation (BMT), and chronic blood transfusion (CBT). Since these treatments vary in their therapeutic intent, efficacy in preventing progression ...

Anti-inflammatory therapies for cardiovascular disease.

Atherothrombosis is no longer considered solely a disorder of lipoprotein accumulation in the arterial wall. Rather, the initiation and progression of atherosclerotic lesions is currently understood to have major inflammatory influences that encompass components of both the innate and acquired immune systems. Promising clinical data for 'upstream' biomarkers of inflammation such as interleukin-...

Pre-travel Health Advice for Patients With Cardiovascular Disease

Cardiovascular disease (CVD) is the leading cause of death among international travellers. Practitioner knowledge of the effects of CVD on international travel is imperative in order to promote a healthy travel experience. This review aimed to explore the available literature on this topic. The PubMed database was accessed to source relevant literature using combinations of relevant keywords as...

Mitophagy: New Insight into the Cardiovascular Aging  

Dietary Interventions, Cardiovascular Aging, and Disease

In recent years, a range of dietary interventions have been proposed as alternative to drugs for the prevention and treatment of cardiovascular and other age-related diseases. This is in part because of research demonstrating the beneficial effects of specific dietary interventions in reducing risk factors associated with cardiovascular diseases (CVD), as well as mortality from CVD in both nonh...