Molecular targeted therapy in myeloma and lymphoma
نویسندگان
چکیده
منابع مشابه
Targeted therapy in lymphoma
Discovery of new treatments for lymphoma that prolong survival and are less toxic than currently available agents represents an urgent unmet need. We now have a better understanding of the molecular pathogenesis of lymphoma, such as aberrant signal transduction pathways, which have led to the discovery and development of targeted therapeutics. The ubiquitin-proteasome and the Akt/mammalian targ...
متن کاملTargeted therapy in multiple myeloma.
BACKGROUND Multiple myeloma (MM) is an incurable malignancy. Recent insights into its biology has allowed the use of novel therapies targeting not only the deregulated intracellular signaling in MM cells but also its interaction with the bone marrow microenvironment that confers drug resistance, growth, and survival advantage to the malignant cells. METHODS We review and summarize the recent ...
متن کاملClinical Studies of Molecular Targeted Therapy for Multiple Myeloma
Multiple myeloma (MM) is the second most common hematological malignancy of plasma cells which still remains incurable despite conventional and high-dose chemotherapies. With the introduction of new agents, such as bortezomib, thalidomide, and lenalidomide, there has been significant improvement in treatment outcomes for MM during the last decade. Furthermore, several new novel agents those off...
متن کاملDiffuse large B cell lymphoma: molecular targeted therapy.
Diffuse large B cell lymphoma (DLBCL) is a biologically heterogeneous disease and the most common subtype of B cell non-Hodgkin's lymphoma in the USA. Even though it is a curable lymphoma in advanced stages, up to 40 % of patients eventually relapse or fail to achieve remission. Improved understanding of the biologic complexity of DLBCL reveals a diverse range of oncogenic driver mutations and ...
متن کاملTargeted therapy in relapsed classical hodgkin lymphoma.
Although frontline treatment of advanced Hodgkin lymphoma (HL) produces high cure rates, disease either will not respond to or will relapse after initial therapy in approximately a quarter of patients. Many patients with disease relapse can be successfully salvaged with second-line chemotherapy followed by autologous stem cell transplantation (ASCT). Patients whose disease relapses after ASCT a...
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ژورنال
عنوان ژورنال: Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
سال: 2014
ISSN: 0030-1558,1882-4528
DOI: 10.4044/joma.126.143