Molecular Targeted Therapy in Myelodysplastic Syndromes: New Options for Tailored Treatments

New Treatments for Myelodysplastic Syndromes

In the last decade, significant advances have been made in the treatment of patients with Myelodysplastic Syndromes (MDS). Although best supportive care continues to have an important role in the management of MDS, to date the therapeutic approach is diversified according to the IPSS risk group, karyotype, patient's age, comorbidities, and compliance. Hematopoietic growth factors play a major r...

Lenalidomide: targeted anemia therapy for myelodysplastic syndromes.

Lenalidomide, an IMiD drug (a novel type of immunomodulating drug) was recently approved by the US Food and Drug Administration for the treatment of transfusion-dependent anemia in patients with myelodysplastic syndromes (MDS) and interstitial deletions of chromosome 5q [del(5q)]. This review examines the clinical experience from the MDS-001 and MDS-003 clinical trials that led to this approval...

Treatment options for myelodysplastic syndromes.

Cancer Control 7 but this approach is unlikely to change the natural history of the disorder. Despite the recent approval of azacitidine, supportive care alone will remain an important treatment option for many patients with MDS. Supportive care consists of transfusions for symptomatic anemia or symptomatic thrombocytopenia, treatment of infections with antibiotics,and growth factors designed t...

Treatment Options in Myelodysplastic Syndromes

Molecular Pathogenesis of Myelodysplastic Syndromes

Myelodysplastic syndromes (MDS) are a group of clonal hematologic disorders characterized by inefficient hematopoiesis, hypercellular bone marrow, dysplasia of blood cells and cytopenias. Most patients are diagnosed in their late 60s to early 70s. MDS is a risk factor for the development of acute myeloid leukemia which can occur in 10-15% of patients with MDS. A variety of pathophysiologic mech...