Molecular Profiling of Direct Xenograft Tumors Established from Human Pancreatic Adenocarcinoma After Neoadjuvant Therapy
نویسندگان
چکیده
منابع مشابه
Successful retreatment with chemoradiotherapy for local recurrence of pancreatic adenocarcinoma after neoadjuvant therapy and pancreaticoduodenectomy.
CASE REPORT A 68-year-old man with a history of diabetes and alcohol abuse presented with constitutional symptoms and obstructive jaundice in April 2009. Endoscopic ultrasound (EUS) demonstrated a 3.2 2-cm mass in the head of the pancreas, abutting the portal vein and encasing the common bile duct. A biopsy was positive for adenocarcinoma, and the tumor was judged to be borderline resectable. T...
متن کاملAdvances in Molecular Profiling and Categorisation of Pancreatic Adenocarcinoma and the Implications for Therapy
Pancreatic ductal adenocarcinoma (PDAC) continues to be a disease with poor outcomes and short-lived treatment responses. New information is emerging from genome sequencing identifying potential subgroups based on somatic and germline mutations. A variety of different mutations and mutational signatures have been identified; the driver mutation in around 93% of PDAC is KRAS, with other recorded...
متن کاملNeoadjuvant therapy in pancreatic cancer
The overall survival for carcinoma pancreas is still around 5%. Surgical resection alone is associated with a low survival and high recurrence rates. Neoadjuvant therapy for carcinoma pancreas is aimed at improving survival and resectability by downsizing borderline resectable and unresectable tumors. However its role in the resectable group of patients is still not clear. This review discussed...
متن کاملMolecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer.
The molecular basis of pancreatic cancer is not understood. Previous attempts to determine the specific genes expressed in pancreatic cancer have been hampered by similarities between adenocarcinoma and chronic pancreatitis. In the current study, microarrays (Affymetrix) were used to profile gene expression in pancreatic adenocarcinoma (10), pancreatic cancer cell lines (7), chronic pancreatiti...
متن کاملMolecular pathobiology of pancreatic adenocarcinoma.
Pancreatic adenocarcinoma is a major cause of cancer death in the United States. Most cases are sporadic and are discovered at late stage when they are not curable by surgery. Information about the molecular biology of pancreatic adenocarcinoma has increased significantly in the last five years with the identification of alterations in the K-ras proto-oncogene and the p16INK4a, p53, FHIT, and D...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annals of Surgical Oncology
سال: 2011
ISSN: 1068-9265,1534-4681
DOI: 10.1245/s10434-011-1839-4