Molecular Physiology of Mammalian Glucokinase
نویسندگان
چکیده
منابع مشابه
Mammalian glucokinase and its gene.
Mammalian glucokinase was identified 30 years ago as a distinct form of hexokinase in rat liver. The hexokinases (ATP: hexose 6phosphotransferases, EC 2.7.1.1) constitute a family of evolutionarily and stucturally related enzymes present in eukaryotic cells from yeast to mammals. In the cells of higher organisms, the physiologically significant substrate for these enzymes is Dglucose. The react...
متن کاملMammalian distal tubule: physiology, pathophysiology, and molecular anatomy.
The distal tubule of the mammalian kidney, defined as the region between the macula densa and the collecting duct, is morphologically and functionally heterogeneous. This heterogeneity has stymied attempts to define functional properties of individual cell types and has led to controversy concerning mechanisms and regulation of ion transport. Recently, molecular techniques have been used to ide...
متن کاملMolecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase.
Glucokinase (GK) is a monomeric allosteric enzyme and plays a pivotal role in blood glucose homeostasis. GK is regulated by GK regulatory protein (GKRP), and indirectly by allosteric effectors of GKRP. Despite the critical roles of GK and GKRP, the molecular basis for the allosteric regulation mechanism of GK by GKRP remains unclear. We determined the crystal structure of Xenopus GK and GKRP co...
متن کاملThe Physiology of Mammalian Temperature Homeostasis
Preface Mammalian temperature regulation has been the subject of scientific investigation since the advent of thermometers that could be inserted into an orifice of the body. Thousands of research articles, review articles, and book chapters have been written on the subject. A substantial portion of the Handbooks of Physiology Section 4: Environmental Physiology (American Physiological Society,...
متن کاملGlucokinase and molecular aspects of liver glycogen metabolism.
Conversion of glucose into glycogen is a major pathway that contributes to the removal of glucose from the portal vein by the liver in the postprandial state. It is regulated in part by the increase in blood-glucose concentration in the portal vein, which activates glucokinase, the first enzyme in the pathway, causing an increase in the concentration of glucose 6-P (glucose 6-phosphate), which ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cellular and Molecular Life Sciences
سال: 2008
ISSN: 1420-682X,1420-9071
DOI: 10.1007/s00018-008-8322-9