Molecular Models of Human Elastin and Elastin Biomaterials

Crosslinked alpha-elastin biomaterials: towards a processable elastin mimetic scaffold.

Elastin is a critical biochemical and biomechanical component of vascular tissue. However, elastin is also highly insoluble and therefore difficult to process into new biomaterials. We present a simple approach for synthesizing elastin-based materials from two commercially available and water-soluble components: alpha-elastin and a diepoxy crosslinker. Reaction pH was shown to modulate the degr...

Molecular biology and pathology of human elastin.

22. M., Ninomiya, Y. & Olsen, H. K. (198%) J. Hiol. Chem. 263.2324-2329 Yada, T., Suzuki. S., Kobayashi, K., Kobayashi, M., Hoshino, T., Horie. K. & Kimata, K. (1000) J. Hiol. Chem. 265,6092-6990 Gordon. M. K., Gerecke, L). R. & Olsen, H. K. (1 987) I’roc. Natl. Acad. Sci. LISA. 84. 6040-6044 Llublet, H. & van der Rest, M. (1987) J. Hiol. Chem. 262. 1772417727 Dublet, H., Oh, S., Sugrue, S. I)....

Functional rescue of elastin insufficiency in mice by the human elastin gene: implications for mouse models of human disease.

Diseases linked to the elastin gene arise from loss-of-function mutations leading to protein insufficiency (supravalvular aortic stenosis) or from missense mutations that alter the properties of the elastin protein (dominant cutis laxa). Modeling these diseases in mice is problematic because of structural differences between the human and mouse genes. To address this problem, we developed a hum...

Amyloidogenesis of proteolytic fragments of human elastin

Collagen and elastin fibres.

PROCOLLAGEN-COLLAGEN CONVERSION The first extracellular step after secretion is the proteolytic cleavage of these Nand C-terminal nonhelical regions of procollagen (Bornstein, 1974). The actual location of cleavage of these extension peptides is not known, but they are probably removed during the formation of the fibre and may take part in fibrogenesis. The intermediates in the conversion of pr...