Molecular Mechanisms of Polybrominated Diphenyl Ethers (BDE-47, BDE-100, and BDE-153) in Human Breast Cancer Cells and Patient-Derived Xenografts
نویسندگان
چکیده
منابع مشابه
Placental transfer of the polybrominated diphenyl ethers BDE-47, BDE-99 and BDE-209 in a human placenta perfusion system: an experimental study
BACKGROUND Polybrominated diphenyl ethers (PBDEs) have been widely used as flame retardants in consumer products. PBDEs may affect thyroid hormone homeostasis, which can result in irreversible damage of cognitive performance, motor skills and altered behaviour. Thus, in utero exposure is of very high concern due to critical windows in fetal development. METHODS A human ex vivo placenta perfus...
متن کاملBioaccumulation, biotransformation, and toxicity of BDE-47, 6-OH-BDE-47, and 6-MeO-BDE-47 in early life-stages of zebrafish (Danio rerio).
2,2',4,4'-Tetrabromodiphenyl ether (BDE-47), 6-hydroxy-tetrabromodiphenyl ether (6-OH-BDE-47), and 6-methoxy-tetrabromodiphenyl ether (6-MeO-BDE-47) are the most detected congeners of polybrominated diphenyl ethers (PBDEs), OH-BDEs, and MeO-BDEs, respectively, in aquatic organisms. Although it has been demonstrated that BDE-47 can interfere with certain endocrine functions that are mediated thr...
متن کاملPolybrominated diphenyl ether congener, BDE-47, impairs insulin sensitivity in mice with liver-specific Pten deficiency
BACKGROUND The potential health effects of polybrominated diphenyl ethers (PBDEs) that are widely used as flame-retardants in consumer products have been attributed, in part, to their endocrine disrupting properties. The purpose of this study is to examine the in vivo effects of an early exposure to PBDEs on the development of insulin resistance in mice. RESULTS The metabolic consequences of ...
متن کاملintegrated biomarker responses of carassius auratus exposed to bde-47, bde-99 and their mixtures
polybrominated diphenyl ethers (pbdes) have been widely used in many products as flameretardants, which resulted in their release into the environment. little is known about the impact of coexisting pbdes on organisms. in this study, the in vivo effects of bde-47 and bde-99 on a suite of biomarkers, acetyl cholinesterase (ache), ethoxyresorufin-o-deethylase (erod), glutathione-s-transferase (gs...
متن کاملChanges in antitoxic defense systems of the freshwater amphipod Gammarus pulex exposed to BDE-47 and BDE-99.
Polybrominated diphenyl ethers (PBDEs) are emerging pollutants widely distributed in aquatic environment. Although the bioaccumulation of this compound has been well studied, few studies have investigated their impacts on antitoxic systems of invertebrates, considering both genders. Here, we have evaluated the effects of BDE-47 and BDE-99 congeners on the antitoxic defence systems of the freshw...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2019
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfz054