Molecular Mechanisms of Mismatch Repair Genes in Cancer A Brief Review

Molecular Mechanisms of Mismatch Repair Genes in Cancer – A Brief Review

Cancer, characterized by uncontrolled growth and cell division, has commanded tremendous efforts from the research fraternity in elucidating all plausible pathways that drive a normal cell into the oncogenic pathway. Designing new strategies and protocols for treatment of the disease have been extensively studied yet unsuccessful due to the fact that the diagnosis happens at a very late stage o...

DNA mismatch repair genes and colorectal cancer.

Mismatch repair genes in Lynch syndrome: a review.

Lynch syndrome represents 1-7% of all cases of colorectal cancer and is an autosomal-dominant inherited cancer predisposition syndrome caused by germline mutations in deoxyribonucleic acid (DNA) mismatch repair genes. Since the discovery of the major human genes with DNA mismatch repair function, mutations in five of them have been correlated with susceptibility to Lynch syndrome: mutS homolog ...

Polymorphism of DNA mismatch repair genes in endometrial cancer.

UNLABELLED Endometrial cancer (EC) is the second most common malignancy associated with hereditary non-polyposis colorectal cancer (HNPCC) family. The development of HNPCC is associated with defects in DNA mismatch repair (MMR) pathway resulting in microsatellite instability (MSI). MSI is present in a greater number of EC than can be accounted for by inherited MMR mutations, therefore alternati...

DNA Mismatch Repair (MMR) Genes and Endometrial Cancer