Molecular mechanism of nucleotide excision repair

Molecular mechanism of nucleotide excision repair.

From its very beginning, life has faced the fundamental problem that the form in which genetic information is stored is not chemically inert. DNA integrity is challenged by the damaging effect of numerous chemical and physical agents, compromizing its function. To protect this Achilles heel, an intricate network of DNA repair systems has evolved early in evolution. One of these is nucleotide ex...

Molecular Mechanism of Global Genome Nucleotide Excision Repair

Nucleotide excision repair (NER) is a multistep process that recognizes and eliminates a wide spectrum of damage causing significant distortions in the DNA structure, such as UV-induced damage and bulky chemical adducts. The consequences of defective NER are apparent in the clinical symptoms of individuals affected by three disorders associated with reduced NER capacities: xeroderma pigmentosum...

Nucleotide excision repair, a tracking mechanism in search of damage.

Nucleotide excision repair (NER)l in all organisms, is able to accommodate to virtually any kind of DNA damage unlike many repair systems whose specificity is limited to a single species of damage. As a consequence NER has the advantage of being effective in responding to new types of environmental agents able to damage DNA. The model repair system under extensive study is the Escherichia coli ...

Prokaryotic nucleotide excision repair.

Nucleotide excision repair (NER) has allowed bacteria to flourish in many different niches around the globe that inflict harsh environmental damage to their genetic material. NER is remarkable because of its diverse substrate repertoire, which differs greatly in chemical composition and structure. Recent advances in structural biology and single-molecule studies have given great insight into th...

SnapShot: Nucleotide Excision Repair