Molecular Mechanism of Cardiovascular Damage Induced by Aldosterone

[Molecular mechanism of cardiovascular damage induced by aldosterone].

Although the pro-inflammatory and pro-fibrotic actions of aldosterone on the vasculature have been reported, the effects and molecular mechanisms of aldosterone on endothelial function are yet to be determined. We investigated how aldosterone regulates endothelial nitric oxide synthase (eNOS) function in human umbilical vein endothelial cells (HUVECs). HUVECs were incubated for 16 hrs with 10(-...

A Feasible Mechanism of Molecular Contamination Induced Laser Optic Damage

A mechanism is described for the interaction of vitreous oxide dielectrics in the presence of molecular contamination. The mechanism is based upon well known and documented behaviors of the constituent parts of the laser damage process. It is consistent with nearly all observations of laser optic damage in the presence of molecular contamination. This description is unique in that it describes ...

molecular mechanism of isoniazid-induced mitochondrial toxicity

Mineralocorticoid receptors and cardiovascular damage: it's not just aldosterone.

Adecade before aldosterone was isolated and characterized, Hans Selye showed that administration of deoxycorticosterone acetate to rats sensitized by salt loading produced a vascular inflammatory response (polyarteritis) and tissue fibrosis. Fifty years later, Karl Weber and his colleagues showed that aldosterone and inappropriate salt intake produced cardiac hypertrophy and fibrosis1; this res...

Mechanism of ER Stress-Induced Brain Damage by IP3 Receptor

Deranged Ca(2+) signaling and an accumulation of aberrant proteins cause endoplasmic reticulum (ER) stress, which is a hallmark of cell death implicated in many neurodegenerative diseases. However, the underlying mechanisms are elusive. Here, we report that dysfunction of an ER-resident Ca(2+) channel, inositol 1,4,5-trisphosphate receptor (IP(3)R), promotes cell death during ER stress. Heteroz...