Molecular mechanism of cardiac hypertrophy.
نویسندگان
چکیده
منابع مشابه
[Cardiac hypertrophy: molecular and cellular events].
Cardiac hypertrophy is one of the main ways in which cardiomyocytes respond to mechanical and neurohormonal stimuli. It enables myocytes to increase their work output, which improves cardiac pump function. However, this compensatory mechanism can become overwhelmed by biomechanical stress, thereby resulting in heart failure, which is associated with high morbidity and mortality. The complex mol...
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Increased ventricular expression of several genes, including atrial natriuretic factor (ANF), has been documented in experimental models of cardiac hypertrophy. It remains to be clarified whether altered expression of these genes is a consistent marker of the hypertrophy itself or a marker of some parallel pathogenetic process. Using a transgenic mouse model of hypertrophic cardiomyopathy as a ...
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ژورنال
عنوان ژورنال: Japanese Circulation Journal
سال: 1990
ISSN: 0047-1828,1347-4839
DOI: 10.1253/jcj.54.526