Molecular Insights into the Flavivirus Replication Complex

Flaviviruses are vector-borne RNA viruses, many of which clinically relevant human viral pathogens, such as dengue, Zika, Japanese encephalitis, West Nile and yellow fever viruses. Millions people infected with these viruses around the world each year. Vaccines only available for some members this large virus family, there no effective antiviral drugs to treat flavivirus infections. The unmet need vaccines therapies against flaviviral infections drives research towards a better understanding epidemiology, biology immunology flaviviruses. In review, we discuss basic replication process focus on molecular aspects genome replication. Within virus-induced intracellular membranous compartments, takes place, starting from poly protein expression processing assembly complex, followed by delivery progeny particle sites. We attempt update latest key events during highlight knowledge gaps future studies.