Molecular handles on adaptive mutation

Self-adaptive Mutation in Molecular Evolution

This study is focused on an evolutionary algorithm for automated de novo drug design. It discusses how to improve the mutation operator of such an algorithm. By introducing a weighted mutation scheme it tries to improve the performance of the algorithm as well as facilitating for the use of self-adaptation. The two questions which this study tries to answer are: Does introduction of di erent we...

Airfoil Shape Optimization with Adaptive Mutation Genetic Algorithm

An efficient method for scattering Genetic Algorithm (GA) individuals in the design space is proposed to accelerate airfoil shape optimization. The method used here is based on the variation of the mutation rate for each gene of the chromosomes by taking feedback from the current population. An adaptive method for airfoil shape parameterization is also applied and its impact on the optimum desi...

Contamination of laryngoscope handles.

Despite use of sterile or disposable laryngoscope blades for each patient, disinfection of laryngoscope handles does not routinely occur, and these devices present a potential route of transmission of pathogens between patients and staff. A total of 192 specimens from 64 laryngoscope handles deemed 'ready for patient use' in the anaesthetic rooms of 32 operating theatres were semiquantitatively...

Stable nematic droplets with handles.

We stabilize nematic droplets with handles against surface tension-driven instabilities, using a yield-stress material as outer fluid, and study the complex nematic textures and defect structures that result from the competition between topological constraints and the elasticity of the nematic liquid crystal. We uncover a surprisingly persistent twisted configuration of the nematic director ins...

Feature Identities, Descriptors and Handles