منابع مشابه
Oncogenes and tumor suppressor genes.
The genetic paradigm of cancer — that tumors arise as a consequence of the accumulation of mutations in genes controlling cell proliferation, differentiation or death — is now widely accepted. The purpose of this is lecture provide a review of current knowledge on the various types of cancer genes identified so far in different stages of tumor development. We will also address recent attempts t...
متن کاملOncogenes and tumor suppressor genes.
Breast cancer progression involves multiple genetic events, which can activate dominant-acting oncogenes and disrupt the function of specific tumor suppressor genes. This article describes several key oncogene and tumor suppressor signaling networks that have been implicated in breast cancer progression. Among the tumor suppressors, the article emphasizes BRCA1/2 and p53 tumor suppressors. In a...
متن کاملTumor-Suppressor Genes and Oncogenes
The combination of Dacarbazine (DTIC) with alphainterferon has consistently shown a 30% remission rate in patients with disseminated malignant melanoma (Thomson et al., 1987; Guillou et al., 1989; Mulder et al., 1990). Although some of these remissions, in particular the complete remissions are prolonged, overall results are not satisfactory. Recently, a synergistic effect has been described be...
متن کاملOncogenes and tumor suppressor genes in prostate cancer: a review.
The activation of oncogenes and inactivation of tumor suppressor genes (TSGs) have been implicated in the development of many human and animal malignancies. Changes in certain specific genes have been shown to be of potential value for diagnosis and prognosis, as well as treatment, of some cancers. By contrast, no oncogene has been correlated conclusively at the DNA level with the initiation an...
متن کاملHow do mutated oncogenes and tumor suppressor genes cause cancer?
In recent decades we have been given insight into the process that transforms a normal cell into a malignant cancer cell. It has been recognised that malignant transformation occurs through successive mutations in specific cellular genes, leading to the activation of oncogenes and inactivation of tumor suppressor genes. The further study of these genes has generated much of its excitement from ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer
سال: 1995
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(19951115)76:10<1869::aid-cncr2820761030>3.0.co;2-b