Molecular genetics features of anaplastic thyroid carcinoma
نویسندگان
چکیده
INTRODUCTION: Anaplastic thyroid carcinoma (ATC) is the most aggressive type of cancer accounting for 12% all malignancies. Systemic therapy remains main treatment strategy. Targeted and immunotherapy are prescribed when certain molecular genetic aberrations detected.
 THE AIM: To investigate profile samples anaplastic carcinoma.
 MATERIALS AND METHODS: The study included 37 patients with ATC. Mutation V600E BRAF, mutations in gene NRAS KRAS were detected by allele-specific polymerase chain reaction (AS-PCR). Microsatellite instability (MSI) was determined fragment analysis according to ESMO recommendations. Mutations promoter region TERT used Sanger sequencing. NTRK1, EML4-ALK, PAX8/PPARy и RET/PTC translocations ATC real-time (PCR).
 RESULTS: According results study, frequency mutation BRAF 32.4% (12/37). NRAS, genes 13.5% (n=5). prevalence point food 24.3% (n=9). MSI found 2.7% (1/37) cases anapalastic carcinoma. not CONCLUSION: further specific targets cells will allow personalize tactics
منابع مشابه
Update on Anaplastic Thyroid Carcinoma: Morphological, Molecular, and Genetic Features of the Most Aggressive Thyroid Cancer
Anaplastic thyroid carcinoma (ATC) is the most aggressive form of thyroid cancer. It shows a wide spectrum of morphological presentations and the diagnosis could be challenging due to its high degree of dedifferentiation. Molecular and genetic features of ATC are widely heterogeneous as well and many efforts have been made to find a common profile in order to clarify its cancerogenetic process....
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1 Institute of Molecular Biology and Genetics (IBGM), Valladolid University (Uva), Spanish Research Council (CSIC), C/ Sanz y Fores s/n, 47003 Valladolid, Spain 2Scuola di Medicina e Chirurgia, Università di Bologna, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Anatomia Patologica, Ospedale Bellaria Via Altura 3, 40139 Bologna, Italy 3Dipartimento di Scienze Motorie e del...
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ژورنال
عنوان ژورنال: ?????????? ?????????????? ??????
سال: 2023
ISSN: ['2412-9119', '1028-9984']
DOI: https://doi.org/10.17816/onco115251