Molecular genetic survey of five Japanese families with high-molecular- weight kininogen deficiency

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Molecular genetic survey of five Japanese families with high-molecular-weight kininogen deficiency.

Analyses of the kininogen (KGN) molecule and KGN gene status in five Japanese families with high-molecular-weight (HMW) KGN deficiency were performed by the immunoblotting method with monoclonal antibodies to HMW-KGN, and by the Southern blotting method with the cDNA for human low-molecular-weight prekininogen. No molecular abnormality of KGN was detected in the DNA from four patients with tota...

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Neutrophil adhesion on polyurethanes preadsorbed with high molecular weight kininogen.

Interaction of biomaterials with blood components including neutrophils is responsible for some of the clinical complications that have occurred in cardiopulmonary bypass, hemodialysis, and ventricular assist procedures. The possibility of inhibiting the initial adhesion of neutrophils to biomaterials has been studied extensively, but the problem remains unsolved. In this study, we investigated...

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An essential role of high-molecular-weight kininogen in endotoxemia

In this study, we show that mice lacking high-molecular-weight kininogen (HK) were resistant to lipopolysaccharide (LPS)-induced mortality and had significantly reduced circulating LPS levels. Replenishment of HK-deficient mice with human HK recovered the LPS levels and rendered the mice susceptible to LPS-induced mortality. Binding of HK to LPS occurred through the O-polysaccharide/core oligos...

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Inhibition of cell adhesion by high molecular weight kininogen

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Domain 5 of high molecular weight kininogen is antibacterial.

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ژورنال

عنوان ژورنال: Blood

سال: 1990

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v75.6.1296.1296