Molecular features that predict the response to antimetabolite chemotherapies
نویسندگان
چکیده
منابع مشابه
Molecular features that predict the response to antimetabolite chemotherapies
BACKGROUND Antimetabolite chemotherapeutic agents that target cellular metabolism are widely used in the clinic and are thought to exert their anti-cancer effects mainly through non-specific cytotoxic effects. However, patients vary dramatically with respect to treatment outcome, and the sources of heterogeneity remain largely unknown. METHODS Here, we introduce a computational method for ide...
متن کاملUsing Molecular Features of Xenobiotics to Predict Hepatic Gene Expression Response
Despite recent advances in molecular medicine and rational drug design, many drugs still fail because toxic effects arise at the cellular and tissue level. In order to better understand these effects, cellular assays can generate high-throughput measurements of gene expression changes induced by small molecules. However, our understanding of how the chemical features of small molecules influenc...
متن کاملLearning Features that Predict Cue Usage
Our goal is to identify the features that predict the occurrence and placement of discourse cues in tutorial explanations in order to aid in the automatic generation of explanations. Previous at tempts to devise rules for text generation were based on intuition or small numbers of constructed examples. We apply a machine learning program, C4.5, to induce decision trees for cue occurrence and pl...
متن کاملAnalysis of the molecular features of rectal carcinoid tumors to identify new biomarkers that predict biological malignancy
Although gastrointestinal carcinoid tumors are relatively rare in the digestive tract, a quarter of them are present in the rectum. In the absence of specific tumor biomarkers, lymphatic or vascular invasion is generally used to predict the risk of lymph node metastasis. We, therefore, examined the genetic and epigenetic alterations potentially associated with lymphovascular invasion among 56 p...
متن کاملExpression profiles of osteosarcoma that can predict response to chemotherapy.
Osteosarcoma is the most common malignant bone tumor in children. After initial diagnosis is made with a biopsy, treatment consists of preoperative chemotherapy followed by definitive surgery and postoperative chemotherapy. The degree of tumor necrosis in response to preoperative chemotherapy is a reliable prognostic factor and is used to guide the choice of postoperative chemotherapy. Patients...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer & Metabolism
سال: 2017
ISSN: 2049-3002
DOI: 10.1186/s40170-017-0170-3