Molecular dissection of germ cell development in the planarian Schmidtea mediterranea
نویسندگان
چکیده
منابع مشابه
Cellular, ultrastructural and molecular analyses of epidermal cell development in the planarian Schmidtea mediterranea.
The epidermis is essential for animal survival, providing both a protective barrier and cellular sensor to external environments. The generally conserved embryonic origin of the epidermis, but the broad morphological and functional diversity of this organ across animals is puzzling. We define the transcriptional regulators underlying epidermal lineage differentiation in the planarian Schmidtea ...
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(Shaked etal., PLoS ONE 2008). To further investigate this finding, several different approaches have been taken. First, the expression of HDAC-regulated candidate genes responsible for controlling neurogenesis has been examined through quantitative realtime RT-PCR. TSA-based inhibition of HDAC activity resulted in upregulation of Bmp2, Stat1, Stat3, Ngn1 and Ngn2 in neural precursors from both...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2009
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2009.05.011