Molecular disorganization of axons adjacent to human lacunar infarcts
نویسندگان
چکیده
منابع مشابه
Molecular disorganization of axons adjacent to human lacunar infarcts.
Cerebral microvascular disease predominantly affects brain white matter and deep grey matter, resulting in ischaemic damage that ranges from lacunar infarcts to white matter hyperintensities seen on magnetic resonance imaging. These lesions are common and result in both clinical stroke syndromes and accumulate over time, resulting in cognitive deficits and dementia. Magnetic resonance imaging s...
متن کاملMolecular Disorganization of Axons Adjacent to Human Cortical Microinfarcts
Cortical microinfarcts (CMIs) are microscopically identified wedge-shaped ischemic lesions that occur at or near the cortical surface and result from occlusion of penetrating arterioles. These microscopic lesions can be observed with high-resolution magnetic resonance imaging in aging brains and in patients with cerebrovascular disease. Recent studies have suggested that strategically located m...
متن کاملTwo Types of Lacunar Infarcts
Background and Purpose—Earlier, we found that lacunar stroke patients with 1 asymptomatic lacunar infarcts on CT had leukoaraiosis and hypertension significantly more often than patients without such lesions, and we hypothesized that 2 types of small-vessel disease could be distinguished during life: arteriolosclerosis and microatheromatosis, respectively. Differences in prognosis might sustain...
متن کاملLacunar versus non-lacunar infarcts: pathogenetic and prognostic differences.
To characterise the pathogenetic and prognostic features of lacunar infarcts, 88 patients with these infarcts were compared with 103 patients with non-lacunar infarcts. Potential cardioembolic sources were significantly more frequent among patients with non-lacunar infarcts (p = 0.0025). Although the prevalence of hypertension was higher among lacunar infarcts, this difference was not statistic...
متن کاملMR and CT of lacunar infarcts.
Twenty-two patients with clinical signs and symptoms compatible with lacunar transient ischemic attack or stroke of varying chronicity were evaluated with MR imaging. CT was also performed in 21 of these patients. MR revealed small, deep cerebral lesions in locations appropriate to the clinical symptoms in 19 patients. Lacunar infarcts were imaged by CT in 11 patients; however, no lesions were ...
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ژورنال
عنوان ژورنال: Brain
سال: 2015
ISSN: 1460-2156,0006-8950
DOI: 10.1093/brain/awu398