Molecular determinants of plaque size as an indicator of dengue virus attenuation

Molecular determinants of plaque size as an indicator of dengue virus attenuation

The development of live viral vaccines relies on empirically derived phenotypic criteria, especially small plaque sizes, to indicate attenuation. However, while some candidate vaccines successfully translated into licensed applications, others have failed safety trials, placing vaccine development on a hit-or-miss trajectory. We examined the determinants of small plaque phenotype in two dengue ...

nano-rods zno as an efficient catalyst for the synthesis of chromene phosphonates, direct amidation and formylation of amines

چکیده ندارد.

Molecular markers as an indicator in the malignant potential of oral lichen planus: A systematic review

BACKGROUND AND AIM: Oral lichen planus (OLP) is a chronic, autoimmune, inflammatory disease. The progression of OLP to oral squamous cell carcinoma (OSCC) has generated a longstanding controversy about the details of this malignant transformation potential. This study aimed to do a systematic review on the molecular markers related to the malignant transformation of OLP.METHODS: We searched the...

Molecular analysis of dengue virus attenuation after serial passage in primary dog kidney cells.

The complete nucleotide sequences of the genomes of dengue-1 virus virulent 45AZ5 PDK-O and attenuated vaccine candidate strain 45AZ5 PDK-27 have been determined and compared with the dengue-1 virus Western Pacific (West Pac) 74 parent strain from which 45AZ5 PDK-O was derived. Twenty-five (0.23%) nucleotide and 10 (0.29%) amino acid substitutions occurred between parent strain dengue-1 virus W...

Excessive Attenuation of Measles Virus as a Possible Cause of Failure in Measles Immunization