Molecular Classification of Metaplastic Carcinoma Using Surrogate Immunohistochemical Staining

Molecular classification of metaplastic carcinoma using surrogate immunohistochemical staining.

OBJECTIVE The purpose of this study is to investigate molecular subtyping and its implications on metaplastic carcinoma according to surrogate immunohistochemical (IHC) staining. METHODS Following tissue microarray analysis of 34 cases of metaplastic carcinoma, IHC staining for cytokeratin (CK) 5/6, epidermal growth factor receptor (EGFR), claudin-3, claudin-4, claudin-7, E-cadherin, STAT-1, ...

Metaplastic carcinoma of the breast: an immunohistochemical study

BACKGROUND Metaplastic breast carcinoma is a rare entity of breast cancer expressing epithelial and/or mesenchymal tissue within the same tumor. The aim of this study is to evaluate the clinicopathological features of metaplastic breast carcinoma and to confirm the triple negative, basal-like and/or luminal phenotype of this type of tumor by using immunohistochemical staining. METHODS Seven c...

The Expression of P53 in Leukoplakia, Squamous Cell Carcinoma and Normal Oral Epithelium Using Immunohistochemical Staining Method

Background & Aims: Leukoplakia is the most common premalignant or potentially malignant lesion of the oral mucosa and its potentiality for malignant transformation is unpredictable. The aim of the present study was to evaluate p53 expression in normal oral epithelium, leukoplakia and oral squamous cell carcinoma. Methods: The standard Biotin streptavaidin peroxidase immunohistochemical staining...

Cytoplasmic Her2/neu immunohistochemical staining in breast cancer; From a molecular point of view

Metaplastic Carcinoma of Breast

Metaplastic carcinoma of breast (MBC) is a rare type of invasive breast carcinoma. It poses diagnostic challenge due to its varied histology and diverse differentiation. These are heterogenous group of tumors in which part or whole of the carcinomatous component is transformed into a metaplastic mesenchymal component and runs an aggressive clinical course. We present two cases of metaplastic ca...