Molecular Chaperones and Co-Chaperones in Parkinson Disease
نویسندگان
چکیده
منابع مشابه
Molecular Chaperones and Co-chaperones as Therapeutic Targets for Cancer
Cancer is a devastating disease that has affected millions of people, consumed tremendous efforts in the treatment/care and is incurable. Statistics from www.seer.cancer.gov show 14,140,254 people were living with cancer in 2013 in US with 1,685,210 new cases projected and 595,690 estimated deaths to occur due to cancer in 2016. Number of people surviving cancer (measured as 5-year survival rat...
متن کاملMolecular Chaperones in Cardiovascular Biology and Disease
How a cell responds to stress is a central problem in cardiovascular biology. Diverse physiological stresses (eg, heat, hemodynamics, mutant proteins, and oxidative injury) produce multiple changes in a cell that ultimately affect protein structures and function. Cells from different phyla initiate a cascade of events that engage essential proteins, the molecular chaperones, in decisions to rep...
متن کاملMolecular Chaperones
In most cases proteins fold spontaneously under physiological conditions and do not require any external assistance. This has become evident since the experiments on ribonuclease A conducted by Anfinsen in ‘50s and ‘60s. The list of such “successful” folders has grown since and now includes many two-state proteins catalogued in Folding & Design 3, R81. These proteins fold rapidly and reliably t...
متن کاملThe many roles of molecular chaperones and co-chaperones in tumour biology.
Molecular chaperones (heat-shock proteins, Hsps) are proteins that maintain intracellular homeostasis through folding and stabilisation of the conformation of other proteins. Molecular chaperones are critical for survival of cells that undergo cellular stress due to their ability to guard the proteome against misfolded proteins and aggregation. In addition to their canonical role in basic cellu...
متن کاملParkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models
GBA gene mutations are the greatest cause of Parkinson disease (PD). GBA encodes the lysosomal enzyme glucocerebrosidase (GCase) but the mechanisms by which loss of GCase contributes to PD remain unclear. Inhibition of autophagy and the generation of endoplasmic reticulum (ER) stress are both implicated. Mutant GCase can unfold in the ER and be degraded via the unfolded protein response, activa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Neuroscientist
سال: 2012
ISSN: 1073-8584,1089-4098
DOI: 10.1177/1073858412441372