Molecular biology and transductional features of 5-HT4 receptors

Molecular biology and respiratory disease. 5. Molecular biology of receptors: implications for lung disease.

Distribution of 5-HT3, 5-HT4, and 5-HT7 Receptors Along the Human Colon

BACKGROUND/AIMS Several disorders of the gastrointestinal tract are associated with abnormal serotonin (5-HT) signaling or metabolism where the 5-HT3 and 5-HT4 receptors are clinically relevant. The aim was to examine the distribution of 5-HT3, 5-HT4, and 5-HT7 receptors in the normal human colon and how this is associated with receptor interacting chaperone 3, G protein coupled receptor kin-as...

Molecular biology of olfactory receptors.

OR proteins bind odorant ligands and transmit a G-protein-mediated intracellular signal, resulting in generation of an action potential. The accumulation of DNA sequences of hundreds of OR genes provides an opportunity to predict features related to their structure, function and evolutionary diversification. The OR repertoire has evolved a variable ligand-binding site that ascertains recognitio...

Molecular biology of opioid receptors.

Opium and its derivatives are potent analgesics that also have many other pharmacological effects in the nervous system. These agents and the endogenous opioid peptides exert their effects by interacting with high-affinity receptors. Complementary DNAs encoding the delta, kappa and mu opioid receptors have been isolated and characterized. These receptors, which are members of the superfamily of...

Session 5 : Molecular Biology

not provided. [09.30–09.50] ‘Rapid discovery and optimization of therapeutic human antibodies using Adimabs yeast based discovery platform’ Jonathan Belk Adimab Inc., Lebanon, NH, USA We have created a synthetic antibody library with diversity that closely mimics the key features of the pre-immune process of VDJ recombination. This library has been synthesized and introduced into a novel yeast ...