Molecular aspects of tight junction barrier function
نویسندگان
چکیده
منابع مشابه
PLEKHA7 modulates epithelial tight junction barrier function
PLEKHA7 is a recently identified protein of the epithelial zonula adhaerens (ZA), and is part of a protein complex that stabilizes the ZA, by linking it to microtubules. Since the ZA is important in the assembly and disassembly of tight junctions (TJ), we asked whether PLEKHA7 is involved in modulating epithelial TJ barrier function. We generated clonal MDCK cell lines in which one of four diff...
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Upon barrier disturbance, adult CD44 knockout (KO) mice show delayed recovery of epidermal barrier function. This correlates with the loss of apical polarization of lamellar body (LB) secretion. As tight junctions (TJs) are crucial for barrier function and regulate polarized targeting of vesicles, we hypothesized that CD44 regulates TJs and associated cell polarity complexes, which in turn cont...
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ژورنال
عنوان ژورنال: Current Opinion in Pharmacology
سال: 2014
ISSN: 1471-4892
DOI: 10.1016/j.coph.2014.07.017