منابع مشابه
Molecular aspects of severe malaria.
Human infections with Plasmodium falciparum may result in severe forms of malaria. The widespread and rapid development of drug resistance in P. falciparum and the resistance of the disease-transmitting mosquitoes to insecticides make it urgent to understand the molecular background of the pathogenesis of malaria to enable the development of novel approaches to combat the disease. This review f...
متن کاملClinical and molecular aspects of severe malaria.
The erythrocytic cycle of Plasmodium falciparum presents a particularity in relation to other Plasmodium species that infect man. Mature trophozoites and schizonts are sequestered from the peripheral circulation due to adhesion of infected erythrocytes to host endothelial cells. Modifications in the surface of infected erythrocytes, termed knobs, seem to facilitate adhesion to endothelium and o...
متن کاملMolecular aspects of malaria pathogenesis.
Plasmodium falciparum being the most lethal plasmodiae is still a major cause of the disease burden and mortality in malaria endemic areas. Due to the wide spread drug resistance in combination with poor socio-economic situation in the vast majority of the endemic countries, malaria is today a great global challenge. The scientific community is, however, progressing. The 23 Mb genome of P. falc...
متن کاملMolecular basis of severe malaria.
M alaria is an ancient scourge that continues to plague many regions of the developing world. Despite its long history, many aspects of the disease remain difficult to explain. For example, why some individuals experience relatively mild symptoms and others progress to severe and sometimes lethal disease is not understood. Similarly, the molecular basis for immunity to severe malaria is poorly ...
متن کاملClinical Aspects of Uncomplicated and Severe Malaria
The first symptoms of malaria, common to all the different malaria species, are nonspecific and mimic a flu-like syndrome. Although fever represents the cardinal feature, clinical findings in malaria are extremely diverse and may range in severity from mild headache to serious complications leading to death, particularly in falciparum malaria. As the progression to these complications can be ra...
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ژورنال
عنوان ژورنال: Clinical Microbiology Reviews
سال: 2000
ISSN: 0893-8512
DOI: 10.1128/cmr.13.3.439-450.2000