Molecular analysis of heritable mouse mutations.
نویسندگان
چکیده
منابع مشابه
Molecular analysis of heritable mouse mutations.
Germ-line mutations of the mouse have for years comprised one class of biological markers for mammalian reproductive and developmental toxicology. Understanding the molecular nature of mutations and the mechanisms by which mutations are translated into specific (and often complex) phenotypes, however, still looms as a major goal of mammalian biology. Molecular genetic analysis of heritable mous...
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Human genetic studies during the past decade have unmasked the molecular pathogenesis of several Mendelian disorders affecting glomerular integrity. Among these disorders are heritable causes of nephrotic syndrome having either autosomal dominant or recessive inheritance, many of which are associated with mutations in genes essential for podocyte structure and function. In addition, systemic ge...
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The study of animal models of heritable cerebrovascular diseases can improve our understanding of disease mechanisms, identify candidate genes for related human disorders, and provide experimental models for preclinical trials. Here we describe a spontaneous mouse mutation that results in reproducible, adult-onset, progressive, focal ischemia in the brain. The pathology is not the result of hem...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1987
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.877441