Molecular actions guiding neural regeneration in planarian
نویسندگان
چکیده
منابع مشابه
Nanotechnology-Based Approaches for Guiding Neural Regeneration.
The mammalian brain is a phenomenal piece of "organic machinery" that has fascinated scientists and clinicians for centuries. The intricate network of tens of billions of neurons dispersed in a mixture of chemical and biochemical constituents gives rise to thoughts, feelings, memories, and life as we know it. In turn, subtle imbalances or damage to this system can cause severe complications in ...
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The principles underlying regeneration in planarians have been explored for over 100 years through surgical manipulations and cellular observations. Planarian regeneration involves the generation of new tissue at the wound site via cell proliferation (blastema formation), and the remodeling of pre-existing tissues to restore symmetry and proportion (morphallaxis). Because blastemas do not repla...
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The fresh water planarian species Schmidtea mediterranea is an emerging stem cell model because of its capability to regenerate a whole animal from a small piece of tissue. It is one of the best model systems to address the basic mechanisms essential for regeneration. Here, we are interested in studying the roles of various amines, thiols and nucleotides in planarian regeneration, stem cell fun...
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Regeneration requires both potential and instructions for tissue replacement. In planarians, pluripotent stem cells have the potential to produce all new tissue. The identities of the cells that provide regeneration instructions are unknown. Here, we report that position control genes (PCGs) that control regeneration and tissue turnover are expressed in a subepidermal layer of nonneoblast cells...
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In 1901, Thomas Hunt Morgan wrote: " The fact that the process of regener-ation is useful to the organism cannot be made to account for its existence in the organism " (Morgan, 1901). Although such words may strike us today as being counter to the general concepts of natural selection, Morgan reached this conclusion after an exhaustive study of regeneration in both plants and animals (Morgan, 1...
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ژورنال
عنوان ژورنال: Neuroscience Bulletin
سال: 2008
ISSN: 1673-7067,1995-8218
DOI: 10.1007/s12264-008-0610-8