Modulation of rod photoreceptor output by HCN1 channels is essential for regular mesopic cone vision
نویسندگان
چکیده
منابع مشابه
Rod and Cone Contributions to Mesopic Vision
Mesopic light levels span approximately 3-4 log units in the natural viewing environment, including many indoor lighting settings, and most twilight or nighttime outdoor and traffic lighting environments. Traditional studies of the contribution of the different photoreceptor types to mesopic vision have been hampered by an inability to modulate the rod or cone systems independently. Our approac...
متن کاملLow-conductance HCN1 ion channels augment the frequency response of rod and cone photoreceptors.
Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels are expressed in several tissues throughout the body, including the heart, the CNS, and the retina. HCN channels are found in many neurons in the retina, but their most established role is in generating the hyperpolarization-activated current, I(h), in photoreceptors. This current makes the light response of rod and cone pho...
متن کاملMesopic and Photopic Rod and Cone Photoreceptor-Driven Visual Processes in Mice With Long-Wavelength-Shifted Cone Pigments.
Purpose The clearer divergence in spectral sensitivity between native rod and human L-cone (L*-cone) opsins in the transgenic Opn1lwLIAIS mouse (LIAIS) allows normal visual processes mediated by these photoreceptor subtypes to be isolated effectively using the silent substitution technique. The objective of this study was to further characterize the influence of mean luminance and temporal freq...
متن کاملLateral suppression of mesopic rod and cone flicker detection.
This study investigated the mechanisms of flicker detection suppression by measuring mesopic rod and cone critical flicker frequencies (CFFs) at different center and surround illuminance levels. Stimuli were generated with a four-primary photostimulator that provided independent control of rod and cone excitations. The results showed that dim surrounds ≤0.2 Td suppressed cone-mediated CFFs at ≥...
متن کاملHCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure
PURPOSE Vision originates in rods and cones at the outer retina. Already at these early stages, diverse processing schemes shape and enhance image information to permit perception over a wide range of lighting conditions. In this work, we address the role of hyperpolarization-activated and cyclic nucleotide-gated channels 1 (HCN1) in rod photoreceptors for the enhancement of rod system responsi...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2011
ISSN: 2041-1723
DOI: 10.1038/ncomms1540