Modulation of nuclear receptor dependent transcription
نویسندگان
چکیده
منابع مشابه
Deoxyribonucleic acid response element-dependent regulation of transcription by orphan nuclear receptor estrogen receptor-related receptor gamma.
The estrogen receptor-related receptor gamma (ERR gamma/ERR3/NR3B3) is the newest member of the ERR subfamily that also includes ERR alpha and ERR beta. All three isoforms share a high degree of amino acid identity especially in the DNA binding domain. ERR gamma is a constitutively active transcriptional activator that regulates reporter elements driven by steroidogenic factor 1 response elemen...
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Objective. To study the effect of immunomodulators on learning and memory and on cholinergic receptor sensitivity. Methods. Animals were initially treated for a period of 8 days with cyclosporine/levamisole/saline. They were then subjected to passive avoidance training and 48 hrs later, the retention test for the passive avoidance task was conducted. Twenty-four hours after the retention tests ...
متن کاملEditorial expression of concern: Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules.
BIOCHEMISTRY PNAS is publishing an Editorial Expression of Concern regarding the following article: “Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules,” by Qidong Hu, Young-Soo Kwon, Esperanza Nunez, Maria Dafne Cardamone, Kasey R. Hutt, Kenneth A. Ohgi, Ivan Garcia-Bassets, David W. Rose, Christopher K.Glass,Mi...
متن کاملPNRC is a unique nuclear receptor coactivator that stimulates RNA polymerase III-dependent transcription
BACKGROUND PNRC transcriptionally regulates a wide range of RNA polymerase (pol) II-transcribed genes by functioning as a nuclear receptor coactivator. To search for additional PNRC-interacting proteins other than nuclear receptors, a PNRC fragment was used as bait in a yeast two-hybrid screening of a human mammary gland cDNA expression library. RESULTS RNA pol III/RPC39 fragments were repeat...
متن کاملNuclear Receptor-Enhanced Transcription Requires Motor- and LSD1-Dependent Gene Networking in Interchromatin Granules
While the transcriptional machinery has been extensively dissected at the molecular level, little is known about regulation of chromosomal organization in the three-dimensional space of the nucleus to achieve integrated transcriptional responses to diverse signaling events. Here, we report that ligand induces rapid interchromosomal interactions among subsets of estrogen receptor alpha-bound tra...
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ژورنال
عنوان ژورنال: Biological Research
سال: 2002
ISSN: 0716-9760
DOI: 10.4067/s0716-97602002000200021