Modulation of immune homeostasis by commensal bacteria
نویسندگان
چکیده
منابع مشابه
Commensal gut bacteria: mechanisms of immune modulation.
Mucosal immune responses to pathogenic gut bacteria and the mechanisms that govern disease progression and outcome have been researched intensely for decades. More recently, the influence of the resident non-pathogenic or 'commensal' microflora on mucosal immune function and gut health has emerged as an area of scientific and clinical importance. Major differences occur in the mucosal immune re...
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For millions of years, microbes have coexisted with eukaryotic cells at the mucosal surfaces of vertebrates in a complex, yet usually harmonious symbiosis. An ever-expanding number of reports describe how eliminating or shifting the intestinal microbiota has profound effects on the development and functionality of the mucosal and systemic immune systems. Here, we examine some of the mechanisms ...
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Immunomodulatory commensal bacteria are proposed to be essential for maintaining healthy tissues, having multiple roles including priming immune responses to ensure rapid and efficient defences against pathogens. The default state of oral tissues, like the gut, is one of inflammation which may be balanced by regulatory mechanisms and the activities of anti-inflammatory resident bacteria that mo...
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M icrobes have a knack for making us sick. Until recently, many of these encounters proved deadly. In Guns, Germs, and Steel, evolutionary biologist Jared Diamond argues that such interactions were a primary force shaping human history. Therefore, it is not surprising that human-microbe interactions often are viewed through the lens of conflict. The proliferation of antibacterial consumer produ...
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During a previous study on the molecular interaction between commensal bacteria and host gut immunity, two novel bacterial strains, A911(T) and G707(T), were isolated from the gut of Drosophila melanogaster. In this study, these strains were characterized in a polyphasic taxonomic study using phenotypic, genetic, and chemotaxonomic analyses. We show that the strains represent novel species in t...
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ژورنال
عنوان ژورنال: Current Opinion in Microbiology
سال: 2011
ISSN: 1369-5274
DOI: 10.1016/j.mib.2010.12.003