Modulation of CD4 + and CD8 + T Cell Function and Cytokine Responses in Strongyloides stercoralis Infection by Interleukin-27 (IL-27) and IL-37
نویسندگان
چکیده
منابع مشابه
SOCS3 regulates CD8 T cell proliferation by inhibition of IL-6 and IL-27
St Vincent’s Institute, Fitzroy, VIC 3065, Australia, Centre for Functional Genomics and Human Disease, Monash Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, VIC 3168, Australia, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, VIC 3050, Australia, Amgen, One Amgen Centre Drive, Thousand Oaks, CA 91320, USA and Ludwig Institute for Cancer Researc...
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Background and purpose: In multiple sclerosis (MS) and its murine model, experimental autoimmune encephalomyelitis (EAE), chronic inflammation damages the myelin of central nervous system. Recently, interleukin-27 (IL-27) has been recognized as a feasible choice for treatment of autoimmune diseases such as MS due to its anti-inflammatory properties. However, the underlying mechanisms have not y...
متن کاملIL-27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infection.
Control of infection caused by Leishmania major requires the development of IFN-gamma+CD4+ lymphocytes for the induction of microbicidal activity in host macrophages. We recently reported on the inability of conventionally resistant C57BL/6 mice to successfully resolve infection by an isolate of L. major, despite a strong IFN-gamma response by the host. Susceptibility was caused by Ag-specific ...
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Interleukin (IL)-30, the IL-27p28 subunit of the heterodimeric cytokine IL-27, acts as an antagonist of IL-27 and IL-6 signaling in murine cells via glycoprotein 130 (gp130) receptor and additional binding partners. Thus far, functions of IL-30 have not been fully elucidated in human cells. We demonstrate that like IL-27, IL-30 upregulated TLR4 expression to enhance lipopolysaccharide-induced T...
متن کاملExpression of IGF-1, IL-27 and IL-35 Receptors in Adjuvant Induced Rheumatoid Arthritis Model
Background: IGF-1 and certain other cytokines have been shown to exert inflammatory/anti-inflammatory roles in chronic joint diseases. Objective: To assess the effect of IGF-1, IL-27 and IL-35, their interaction and their receptor expression in a rheumatoid arthritis model. Methods: Freund’s adjuvant-induced chronic joint inflammation was operated on 160 male rats. Animals were divided into his...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2017
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.00500-17