Modulation of brain polyphosphoinositide metabolism by ACTH and β-endorphin: Structure-activity studies
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منابع مشابه
Modulation of Brain β-Endorphin Concentration by the Specific Part of the Y Chromosome in Mice
BACKGROUND Several studies in animal models suggest a possible effect of the specific part of the Y-chromosome (Y(NPAR)) on brain opioid, and more specifically on brain β-endorphin (BE). In humans, male prevalence is found in autistic disorder in which observation of abnormal peripheral or central BE levels are also reported. This suggests gender differences in BE associated with genetic factor...
متن کاملBrain polyphosphoinositide metabolism during focal ischemia in rat cortex.
Using a rat model of stroke, we examined the effects of focal cerebral ischemia on the metabolism of polyphosphoinositides by injecting 32Pi into both the left and right cortices. After equilibration of the label for 2-3 hours, ischemia induced a significant decrease (p less than 0.001) in the concentrations of labeled phosphatidyl 4,5-bisphosphates (66-78%) and phosphatidylinositol 4-phosphate...
متن کاملPituitary hormones influence polyphosphoinositide metabolism in rat brain.
In a variety of tissues an enhanced metabolism of phosphatidyl inositol (PI) is observed after receptor activation by hormones or neurotransmitters which utilize calcium as second messenger [ 1,2]. The enhancement is manifested by an increased rate of incorporation of Pi into PI and is frequently accompanied by an increase in labelling of phosphatidic acid (PA) [ 11. It is thought to reflect an...
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1. to determine whether difference in birth body mass influenced growth performance in pipistrellus kuhlii we studied a total of 12 captive-born neonates. bats were assigned to two body mass groups: light birth body mass (lbw: 0.89 ± 0.05, n=8) and heavy birth body mass (hbw: 1.35 ± 0.08, n=4). heavier body mass at birth was associated with rapid postnatal growth (body mass and forearm length) ...
Molecular Interpretation of ACTH-β-Endorphin Coaggregation: Relevance to Secretory Granule Biogenesis
Peptide/protein hormones could be stored as non-toxic amyloid-like structures in pituitary secretory granules. ACTH and β-endorphin are two of the important peptide hormones that get co-stored in the pituitary secretory granules. Here, we study molecular interactions between ACTH and β-endorphin and their colocalization in the form of amyloid aggregates. Although ACTH is known to be a part of A...
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ژورنال
عنوان ژورنال: Brain Research
سال: 1981
ISSN: 0006-8993
DOI: 10.1016/0006-8993(81)90862-3