Modulating human aging and age-associated diseases
نویسندگان
چکیده
منابع مشابه
The Biology of Human Longevity, Aging and Age-Associated Diseases
In order to better understand the finitude of life it must be divided into its four components: aging, longevity determination, age-associated disease and death. Age changes result from the increasing rate of biomolecular disorder that, after reproductive maturation, exceeds repair and turnover capacity. These are stochastic or chance events governed by entropy or the tendency for concentrated ...
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Aging is the most significant risk factor for a range of degenerative disease such as cardiovascular, neurodegenerative and metabolic disorders. While the cause of aging and its associated diseases is multifactorial, mitochondrial dysfunction has been implicated in the aging process and the onset and progression of age-associated disorders. Recent studies indicate that maintenance of mitochondr...
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NK cells exhibit the highest cytotoxic capacity within the immune system. Alteration of their number or functionality may have a deep impact on overall immunity. This is of particular relevance in aging where the elderly population becomes more susceptible to infection, cancer, autoimmune diseases, and neurodegenerative diseases amongst others. As the fraction of elderly increases worldwide, it...
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Neurons in the mature human central nervous system (CNS) perform a wide range of motor, sensory, regulatory, behavioral, and cognitive functions. Such diverse functional output requires a great diversity of CNS neuronal and non-neuronal populations. Metabolomics encompasses the study of the complete set of metabolites/low-molecular-weight intermediates (metabolome), which are context-dependent ...
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Institute for Research and Innovation in Health (i3s), University of Porto, 4200-135 Porto, Portugal Department of Biomedicine, Unit of Biochemistry, Faculty of Medicine of the University of Porto (FMUP), 4200-319 Porto, Portugal Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge CB2 0SW, UK Department of Biomedicine, Unit of Experimental Biology, Faculty of Medicine o...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - General Subjects
سال: 2009
ISSN: 0304-4165
DOI: 10.1016/j.bbagen.2009.02.002