Modular Vaccine Design Using Carrier-Free Capsules Assembled from Polyionic Immune Signals
نویسندگان
چکیده
منابع مشابه
Modular Vaccine Design Using Carrier-Free Capsules Assembled from Polyionic Immune Signals
New vaccine adjuvants that direct immune cells toward specific fates could support more potent and selective options for diseases spanning infection to cancer. However, the empirical nature of vaccines and the complexity of many formulations has hindered design of well-defined and easily characterized vaccines. We hypothesized that nanostructured capsules assembled entirely from polyionic immun...
متن کاملPolyionic vaccine adjuvants: another look at aluminum salts and polyelectrolytes
Adjuvants improve the adaptive immune response to a vaccine antigen by modulating innate immunity or facilitating transport and presentation. The selection of an appropriate adjuvant has become vital as new vaccines trend toward narrower composition, expanded application, and improved safety. Functionally, adjuvants act directly or indirectly on antigen presenting cells (APCs) including dendrit...
متن کاملChiral Microenvironments in Self-Assembled Capsules
A nonracemic compound is synthesized and shown to assemble reversibly through hydrogen bonding to form a cyclic tetramer. The chiral arrangement of atoms in the individual pieces becomes amplified through self-assembly to yield multiple functional groups asymmetrically arranged within the cavity. The tetrameric capsule shows a special affinity for ketones and is able to discriminate between the...
متن کاملSelf-Assembled Capsules of Unprecedented Shapes**
Reversible encapsulation allows the temporary isolation of molecules in very small spaces. There, molecular behavior is quite different than that in bulk solvent; in capsules recognition can be amplified, reactive intermediates can be stabilized, reactions can be accelerated or even catalyzed and new reaction pathways can appear. Accordingly, a multitude of capsules have been devised over the l...
متن کاملModular assembled space telescope
We present a new approach to building a modular segmented space telescope that greatly leverages the heritage of the Hubble Space Telescope and the James Webb Space Telescope. The modular design in which mirror segments are assembled into identical panels allows for economies of scale and for efficient space assembly that make a 20-m aperture approach cost effective. This assembly approach can ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: ACS Biomaterials Science & Engineering
سال: 2015
ISSN: 2373-9878,2373-9878
DOI: 10.1021/acsbiomaterials.5b00375